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In ME/CFS, anti-inflammatory bacterial species such as Faecalibacterium (191, 194) and Bifidobacterium (191) are decreased, resulting in a decreased production of anti-inflammatory butyrate (191, 194)

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Advanced formulations using enteric coating, nanoparticle encapsulation, or lipid carriers can raise absorption meaningfully, but human pharmacokinetic data for most research peptides in oral form remain sparse